Endocrine Abstracts

Introduction: Known as a potent anabolic drug, teriparatide has a stimulating effect on bone formation, increasing bone mineral density (BMD) and reducing fracture risk.Methods: 11 Caucasian women (mean age 66 years old) with severe osteoporosis treated with recombinant human parathyroid hormone (1–34) – teriparatide (Forsteo) 20 micrograms daily for 24 months were added to the study.BMD at lumbar spine, total hip and f...

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

Background: The importance of carcinoembryonic antigen (CEA) assessment in the evaluation of medullary thyroid carcinoma is well known. The role of CEA in the assessment of other neuroendocrine tumors (NET) is not clear. We aimed to evaluate a possible correlation between CEA measurements and the aggressivity of NETs.Methods: We evaluated 56 (36 women) NETs followed in a tertiary center (23 gastrointestinal, 12 pancreatic, 10 pulmonary, 7 without primary...

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

Introduction: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor derived from C cells that is responsible for approximately 5% of the gland malignancies, most of them occuring sporadically. Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic factor. Surgery is the only curative therapy while other chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostat...

Introduction: Besides medullary thyroid carcinoma (MTC), increased calcitonin serum concentrations may be due, rarely, to neuroendocrine tumour (NET) ectopic secretion, especially those of the foregut (pancreatic/lung). Patients with NETs and right-sided heart failure due to cardiac carcinoid have a worse prognosis than those presenting without. Case presentation: We present the case of a 72-year-old female with a history of an initially considered well-...

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

Introduction: There is evidence that SARS-COV-2 infection can result in development of endocrine disturbances. Expression of the angiotensin-converting enzyme 2, which is postulated to be at the center of the pathogenesis of COVID-19, has been reported in various endocrine tissues.Case Series: We retrospectively analyzed 12 patients with recent history of SARS-COV-2 infection: 5 cases with subacute thyroiditis (SAT), 2 cases with Graves’ disease, 2 ...